Pregabalin

What is Pregabalin Used For?

A pregabalin tablet is generally used as an anti-convulsant. The primary function of this medication is to treat seizures, as approved by the food and Drug administration (FDA). However, there are other reasons to buy pregabalin.

FDA-approved uses include the treatment or management of:

• Neuropathic pain from diabetes, spinal cord injury and shingles (an infection caused by the herpes zoster virus)
• Fibromyalgia

Off-label uses include:

• Anxiety
• Lower back pain
• Alcohol withdrawal syndrome
• Migraines

The success of pregabalin in seizures

Active epilepsy is presented with a prevalence of 0.5 to 1% of adults. Approximately 70% of people diagnosed with epileptic seizures are able to control the effects using a single anti-epileptic medication. Others may require additional medicines as add-on treatments for the management of this disorder. According to Mollamohammadi et al. (2014), pregabalin was effective in treating refractory seizures in adults and children. The patients were monitored and analyzed one month and four months after beginning treatment. Some showed up to a 50% reduction in seizure activity.

The success of pregabalin as anti-anxiety medication

The World Federation of Biological Psychiatry recommends using a pregablin dose as a first-line treatment for generalized anxiety disorder (GAD). Lyrica is approved in Europe for the treatment of this anxiety disorder.

Randomized controlled studies conducted by Baldwin and other researchers (2013) indicated the use of pregabalin for both acute treatment and the prevention of relapse of GAD. This study concluded that the anxiolytic medication was efficacious in reducing the symptoms of this disorder physically and physiologically. In addition, there was also a visible reduction in the co-existing symptoms of depression.

The success of pregabalin in neuralgia

A pregabalin tablet can be considered a first-line treatment of post-herpetic neuralgia, central neuropathic pain and diabetic neuropathy. This recommendation comes from the European Federation of Neurological Societies. Pregabalin is considered equal in efficacy to tricyclic depressants. In addition, pregabalin was the first medication to receive FDA approval for diabetic neuropathy and post-herpetic neuralgia treatment.

The major advantage of this analgesic is its reliability, high tolerance and ease of administration in patients with neuropathic pain (Verma et al., 2014). Re-clinical and clinical studies have proved the effectiveness of pregabalin in neuralgia.

The success of pregabalin for fibromyalgia

This disorder involves intense musculoskeletal pain and can be accompanied by fatigue, sleep disturbances and changes in moods. Anyone can develop fibromyalgia but the typical trend observed is that this disorder is prevalent in women.

Boomershine (2010) conducted a study investigating the use of pregabalin in fibromyalgia patients. The study revealed that this treatment was useful in improving the sleeping patterns, reduced pain and increasing the quality of life in these patients. The improvements of fatigue and anxiety related to this disorder were also shown to be statistically significant.

The success of pregabalin for low back pain

Low back pain ranks within the top 10 conditions responsible for the highest number of disability-adjusted lifestyles around the globe. It is one of the most frequent complaints of patients. Okur et al. (2018) researched the use of pregabalin for low back pain. They suggested that this type of chronic pain has two components, namely, nociceptive and neuropathic. For the neuropathic component, it is advised to buy pregabalin as this study indicated the efficacy of the analgesic is significant.

How Does Pregabalin Work?

Brain cells operate at a specific rate for normal body functioning. Seizures affect these operations by forcing the brain cells to work much quicker than they generally do. It is not well established how pregabalin works to stop seizure activity but there some theories to the mechanisms of action. It is thought that the basic mode of action is for the anti-epileptic medication to prevent the brain cells to function as rapidly as seizures affect them to.

Pregabalin is classified as a gabapentinoid. Gabapentinoids are a class of medicines which are derived from the inhibitory neurotransmitter GABA (gamma-aminobutyric acid). They block the subunits which contain voltage-dependent calcium channels. Even though this class of medicine is a structural analogue of GABA, it is not known to influence the uptake of GABA or interact with GABAA and GABAB receptors.

The most likely target of pregabalin action is the inhibition of the calcium channels. This contributes to a lowered release of excitatory neurotransmitters which consequently inhibits synaptic transmission. Other mechanisms of action for the analgesic properties of this medication can include:

• Excitatory amino acid transportation
• Modulation of potassium channel conductance

Pregabalin Dose Guide

Pregabalin 300 mg is available as a tablet, and as an injection. Tablets come in different strengths, and the dosage that will work for you depends on your physical health. You can buy pregabalin online in all the available strengths. What works for one person may not work for another, so it is important to make sure you are aware of the precautions and contraindications, and seek advice if you are not sure what your dosage should be. Most people start off with a lower dosage and gradually increase it to a regular intake of 2-3 times a day for epilepsy. Higher dosages can be associated with a greater risk of pregabalin side effects. When treating epilepsy, this drug is usually used in conjunction with other types of medication.

Pregabalin dosage for partial onset seizures

Adult dosage guide (18 to 64 years)

• Normal initial dosage: A pregabalin tablet (75mg) taken twice a day, which also quantifies to 50mg of the active ingredient taken three times a day (150mg total dose)
• Dose increments: This is subject to the clinical response of the individual to the treatment
• Maximum dose: 600mg of the anti-epileptic medication, daily

Pediatric dosage guide (4 to 17 years)

• Normal initial dosage: 3.5mg per kg a day (for children 11 kg to 30kg) and 2.5mg per kg a day (for children 30kg or more). This amount may be divided into two or three doses throughout the day)
• Maximum dose: not to exceed 600mg, daily. Typical recommendations include 14mg per kg daily (for children 11 kg to 30kg) and 10mg per kg daily (for children 30kg or more).

Senior dosage guide (65 years and older)

This is an individualized dosage and the dosing schedule depends on the medical history and fitness of the patient.

Pregabalin dosage for diabetic peripheral neuropathy

Adult dosage guide (18 to 64 years)

• Normal initial dosage: A 50mg pregabalin dose which is administered three times a day
• Dose increments: This is subject to the clinical response of the individual to the treatment
• Maximum dose: a daily maximum dose of 300 mg pregabalin (can be divided into three 100 mg doses)

Senior dosage guide (65 years and older)
The elderly are cautioned when using medications. The doses are dependent on their ability to process the ingredients of the medicines. The amount of analgesic administed to seniors is done such that there are minimal pregabalin side effects (these can be found on the material information when you buy pregabalin online).

Pregabalin dosage for shingles

Adult dosage guide (18 to 64 years)

• Normal initial dosage: 75-50mg pregabalin two to three times a day / 50-150mg two to three times a day
• Dose increments: the amount of medicine will be increased depending on how well the patient is responding to the treatment
• Maximum dose: a dose of pregabalin 300 mg taken two times daily or 200mg taken three times a day (total dose of 600 mg)

Senior dosage guide (65 years and older)

Seniors are administered individualized dosages. These are typically lower due to the chance of heightened pregabalin side effects.

Pregabalin dosage for neuropatic pain due to spinal cord injury

Adult dosage guide (18 to 64 years)

• Normal initial dosage: 75mg of the main ingredient in two dosages, daily
• Dose increments: This is an individualized recommendation
• Maximum dose: 300 mg pregabalin may be administered twice a day (to not exceed 600mg)

Senior dosage guide (65 years and older)

If older patients are to use this medication, the dosage will be typically lower than that given to the average adult.

Pregabalin dosage for fibromyalgia

Adult dosage guide (18 to 64 years)

• Normal initial dosage: A 75 mg pregabalin dose administered orally twice a day
• Dose increments: Dependent on the response of patient to the medicine
• Maximum dose: 450mg of the active ingredient per day

Senior dosage guide (65 years and older)

The dosage given to persons older than 65 years of age will depend on how their body can process the medication.

Allergy Warnings

An allergic reaction to this medication should be attended to with urgency. This will be evident by a visible rash on the skin, swelling of the lips, itching and in very serious situations, respiratory difficulties and fever. Allergies to medications occur when the body mistakes the active ingredient as a harmful substance. In attempt to protect the body, the immune system will develop antibodies to this substance it regards as harmful. Treatment discontinuation is the most appropriate route after developing an allergy to certain medicines. Therapeutics which can minimize allergy symptoms can include antihistamines.

Pregabalin Side Effects

Side effects are rarely experienced by people taking pregabalin 300 mg. A few people in the past have reported slightly more severe side effects, but these have usually been the direct result of taking more than the recommended amount or ignoring a contraindicated condition. The most common side effects that have been experienced by one in ten people include the following:

• Dizziness
• Headache
• Dry mouth
• Constipation
• Upset stomach
• Nausea

Speak to a healthcare professional if you have any lingering side effects.

Is Pregabalin 300 mg Safe for Everyone?

Side effects such as those listed above are more likely to occur in the following circumstances:

• In cases where you are allergic to the ingredients contained in this drug
• If you have ever been dependent on drugs or alcohol
• You are currently taking any kind of sleep aid tablets
• If you have ever experienced pregabalin withdrawal
• Pregabalin and alcohol should not be used together
• There has been a diagnosis of a liver/kidney disorder
• Use while you are intending to become pregnant, pregnant or breastfeeding
• If you suffer from any kind of heart condition
• In cases where the patient is less than 18 years old

Note that the side effects and contraindications provided on this website are not exhaustive. If you would like further information, you will find all the information you need online. If you are still uncertain, refer to the patient information booklet provided in the packaging.

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